Group Leader

Prof. Dr. Bruno Weber


We ask very simple questions about the most complex system on the planet. Fascinated by these simple questions and how challenging it is to answer them, my goal is to bring together the very best people with the very best tools. Apart from running the lab for Neuroenergetics and Experimental Imaging, I act as the Director of the Institute of Pharmacology and Toxicology.

Related publications

Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion

Glueck CPNAS

Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain

Herwerth M, Wyss MTbioRXiv

The Astrocyte: Metabolic Hub of the Brain

Barros LFCold Spring Harbor Perspectives in Biology

Leptomeningeal collaterals regulate reperfusion in ischemic stroke

Binder NF, El Amki MNeuron

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health

Looser ZJNature Neuroscience

Sensitive multicolor indicators for monitoring norepinephrine in vivo

Kagiampaki ZNature Communications

Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination fluorescence microscopy

Chen ZBiorxiv

Deep optoacoustic localization microangiography of ischemic stroke in mice

Deán-Ben XLNature Communications

Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

Del Campo Fonseca ANature Communications

SAFIR-I: first NEMA NU 4-2008-based performance characterization

Bebié PEuropean Journal of Nuclear Medicine and Molecular Imaging

Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain

Eleftheriou ANeuroImage

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

Todorova VMolecular Neurodegeneration

Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Berthiaume AANature Communications

A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Duffet LNature Methods

Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation

Zhou QNature Communications

Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency

Stobart JJournal of Cerebral Blood Flow and Metabolism

Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy

Erlebach ESTAR Protocols

Vascular Response to Spreading Depolarization Predicts Stroke Outcome

Binder NFStroke

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Hoesli LCell Reports

Direct vascular contact is a hallmark of cerebral astrocytes

Hoesli LCell Reports

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence

Zhang KNature Neuroscience

Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex.

Rungta RLCommunications Biology

Distinct signatures of calcium activity in brain mural cells

Glueck CeLife

The severity of microstrokes depends on local vascular topology and baseline perfusion

Schmid FeLife

Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

Passini FSNature Biomedical Engineering

DeepVesselNet: Vessel Segmentation, Centerline Prediction, and Bifurcation Detection in 3-D Angiographic Volumes

Tetteh GFrontiers in Neuroscience

Predicting Vessel Diameter Changes to Up-Regulate Biphasic Blood Flow During Activation in Realistic Microvascular Networks

Epp RFrontiers in Physiology

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

Privitera MNature Protocols

A Bright and Colorful Future for G-Protein Coupled Receptor Sensors

Ravotto LFrontiers in Cellular Neuroscience

Structural basis of astrocytic Ca2+ signals at tripartite synapses

Arizono MNature Communications

Arousal-induced cortical activity triggers lactate release from astrocytes

Zuend MNature Metabolism

Initial Characterization of the SAFIR Prototype PET-MR Scanner

Ritzer CIEEE transactions on radiation and plasma medical sciences

Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke

El Amki M, Glueck CCell Reports

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

Zerbi VNeuron

In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

Roche MeLife

Red blood cells stabilize flow in brain microvascular networks

Schmid FPLoS Computational Biology

Oxyphor 2P: A High-Performance Probe for Deep- Tissue Longitudinal Oxygen Imaging

Esipova TVCell Metabolism

Non-Canonical Control of Neuronal Energy Status by the Na+ Pump

Baeza-Lehnert FCell Metabolism

The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 2: Capillary Networks

Lücker AFrontiers in Physiology

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

Stobart JNeuron

The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models

Lücker AFrontiers in Physiology

Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Looser ZJFrontiers in Cellular Neuroscience

DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans

da Silva RVCell Reports

Long-term in vivo calcium imaging of astrocytes reveals distinct cellular compartment responses to sensory stimulation

Stobart JCerebral Cortex

CHIPS: an Extensible Toolbox for Cellular and Hemodynamic Two-Photon Image Analysis

Barrett MJPNeuroinformatics

Stabilizing g‑States in Centrosymmetric Tetrapyrroles: Two-Photon- Absorbing Porphyrins with Bright Phosphorescence

Esipova TVJournal of Physical Chemistry

The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue

Lücker AMicrocirculation

Depth-dependent flow and pressure characteristics in cortical microvascular networks

Schmid FPLoS Computational Biology

The SAFIR experiment: Concept, status and perspectives

Becker RNuclear Instruments and Methods in Physics Research A

Deviant Processing in the Primary Somatosensory Cortex

Musall SCerebral Cortex

Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π‑Extension and Peripheral Substitution

Esipova TVJournal of the American Chemical Society

In vivo evidence for a lactate gradient from astrocytes to neurons

Mächler PCell Metabolism

Design and performance of an ultra-flexible two-photon microscope for in vivo research

Mayrhofer JMBiomedical Optics Express

A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia

Castillo XJournal of Cerebral Blood Flow & Metabolism

NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

Lerchundi RProceedings of the National Academy of Sciences

Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex

Mayrhofer JMNeuroImage

A dynamic model of oxygen transport from capillaries to tissue with movingred blood cells

Lücker AAmerican Journal of Physiology-Heart and Circulatory Physiology

The impact of capillary dilation on the distribution of red blood cells in artificial networks

Schmid FAmerican Journal of Physiology - Heart and Circulatory Physiology

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Sotelo-Hitschfeld TJournal of Neuroscience

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation

Musall SNature Neuroscience

Joint 3-D vessel segmentation and centerline extraction using oblique Hough forests with steerable filters

Schneider MMedical Image Analysis

TGIF: Topological Gap In-Fill for Vascular Networks

Schneider MMedical Image Computing and Computer-Assisted Intervention

Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension

Calcinaghi NStroke

Two-photon microscopy with double-circle trajectories for in vivo cerebral blood flow measurements

Landolt AExperiments in Fluids

Somatotopic Astrocytic Activity in the Somatosensory Cortex

Ghosh AGlia

Novel two-alternative forced choice paradigm for bilateral vibrotactile whisker frequency discrimination in head-fixed mice and rats

Mayrhofer JMJournal of Neurophysiology

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

Spescha RDEuropean Heart Journal

Quantification of brain glucose metabolism by FDG PET with real time arterial and image derived input function in mice

Alf MFJournal of Nuclear Medicine

Reorganization of cortical population activity imaged throughout long-term sensory deprivation

Margolis DJNature Neuroscience

Tissue metabolism driven arterial tree generation

Schneider MMedical Image Analysis

A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate

Lanz BJournal of Cerebral Blood Flow and Metabolism

Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response

Calcinaghi NJournal of Cerebral Blood Flow Metabolism

In vivo evidence for lactate as a neuronal energy source

Wyss MTJournal of Neuroscience

Physiologically based construction of optimized 3-D arterial tree models.

Schneider M Medical Image Computing and Computer-Assisted Intervention

The Microvascular System of the Striate and Extrastriate Visual Cortex of the Macaque

Weber BCerebral Cortex

Related news

1 May 2024
Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more

New Cover in Neuron in Collaboration with Mohamad El Amki and Susanne Wegener

Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more
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1 February 2024
Prof. Dr. Bruno Weber,Dr. Ladina Hösli

The Lab Starts a New Swiss National Science Foundation Project on February 1: Nanoscale Structure of the Microvascular-astrocytic Interface

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Next team member

Dr. Anita Siebert